Dcep dexamethasone, cyclophosphamide, etoposide, and cisplatin has proved to be an effective salvage therapy for refractoryrelapsed mm patients. Cd229 car t cells are highly active in vitro and in vivo against multiple myeloma plasma cells, memory b cells, and mmpropagating cells. Multiple myeloma hematology and oncology merck manuals. The mission of the myeloma beacon is to improve the treatment, care, and support available to current and future multiple myeloma patients worldwide. To accomplish this mission, the beacon has been online since 2008, providing independent and objective news and support to the multiple myeloma community. Multiple myeloma mm is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance mgus to plasma cell leukemia. Table of contents multiple myeloma plasma cell leukemia pre. Treatment options for relapsed or refractory multiple myeloma. International myeloma foundation headquarters 12650 riverside drive, suite 206 north hollywood, ca 91607, usa tel.
Dr mukhtar jama nour, mbbs amoud university for health and science institute 6292014 dr mukhtar jama nour,mbbs 1 what is multiple myeloma. Common manifestations include lytic lesions in bones causing pain, andor fractures, renal insufficiency, hypercalcemia, anemia, and recurrent infections. Dexamethasone for multiple myeloma the intl myeloma fdn. Ensure youre boardexam ready with acps board prep course recordingsa multimedia, selfstudy program that delivers multiple study tools. The myeloma crowd site is the first allinclusive site for myeloma patients and features all of the good being done in the world of myeloma from the various myeloma foundations, patient support groups. Evidence report multiple myeloma return to table of contents executive summary background normally, plasma cells make up less than one percent of cells in the bone marrow. Dexamethasone, cyclophosphamide, etoposide, and cisplatin dcep is one of the salvage options, but there has been a. A plasma cell tumor proven by biopsy or at least 10% plasma cells in the bone marrow and.
Use of krdpace as salvage therapy in aggressive, relapsed. Of patients in whom multiple myeloma developed, those with osseous tumors had a poorer survival rate after development of myeloma 32% vs. It is within the same class as the adrenal corticosteroids prednisone, prednisolone, and methylprednisolone. The average age of people with multiple myeloma is about 65. The links above go to a flowsheet to aid in the determination of disease status for patients with multiple myeloma. Plasma cells are a part of the bodys immune system and produce antibodies that help the body fight infection. Multiple myeloma mm is a hematological cancer in which the bone marrow produces an overabundance of malignant plasma cells.
Electrophoresis the antibody produced by myeloma cells is abnormal because it is monoclonal all the exact same. Multiple myeloma treatment regimens part 1 of 9 clinical trials. Multiple myeloma remains incurable despite the use of novel agents. However, thal is safe in patients with renal failure and can combine well with pis. Criteria for the classification monoclonal gammopathies, multiple myeloma and related disorders. Multiple myeloma blood disorders merck manuals consumer. Treatment options for relapsed or refractory multiple. The nccn recommends cancer patient participation in clinical trials as the gold standard for treatment. Multiple myeloma plasma cell leukemia prehsct data form 2016 document number. Multiple myeloma early detection, diagnosis, and staging. However, the percentage infiltration of mm cells in the bm can vary and be heterogeneous. Anyone else been diagnosed with this that i can chat with. Multiple myeloma multiple myeloma chemotherapy free. Each cycle of dcep consisted of cyclophosphamide 400 mgm2 daily.
Tracking disease status for multiple myeloma word document tracking disease status for multiple myeloma pdf. It is a highly manageable disease that has seen rapid medical advancements in the past few. Dexamethasone which is sometimes called dex for short is also known by the brand names decadron, dexasone, diodex, hexadrol, and maxidex. Treatment options for relapsed and refractory multiple myeloma. Dadacaridou m1, papanicolaou x, maltesas d, megalakaki c, patos p, panteli k, repousis p, mitsoulimentzikof c. Isolation and characterization of human multiple myeloma cell. Multiple myeloma support group meets on the 3rd tuesday of each month from 5. An area that is becoming very important is identifying and separating smoldering multiple myeloma smm from multiple myeloma mm and determining when to start treatment. Isolation and characterization of human multiple myeloma. Dcep for relapsed or refractory multiple myeloma after therapy with.
Bortezomib combination therapy in multiple myeloma ncbi. Dcep an alternative to standard regimen in myeloma. Multiple myeloma may be discovered even before people have symptoms, when laboratory tests done for another reason show elevated protein levels in the blood or protein in the urine, or an xray done for. I was just last week diagnosed with multiple myeloma after a bone marrow biopsy. Conference coverage myeloma patients over age 70 can. This helps you give your presentation on myeloma in a conference, a school lecture, a business proposal, in a webinar and business and professional representations. Ten percent of newly diagnosed myeloma patients treated with any type of chemotherapy develop. Multiple myeloma is a cancer of your plasma cells, a type of white blood cell present in your bone marrow. Conference coverage myeloma patients over age 70 can benefit from autohc transplant author. The combination of dexamethasone, cyclophosphamide, etoposide, and cisplatin dcep is an effective bridge to autologous stem cell transplant asct or novel agents in patients with relapsed refractory multiple myeloma. Multiple myeloma is the most common primary bone tumor in people over 40 years old, and peak incidence occurs in the seventh. Multiple myeloma discharge care what you need to know.
Aug 30, 2017 multiple myeloma patients are at increased risk for developing spinal cord compression due to lytic lesions and compression fractures of the lumbar spine. When the myeloma returns, you will be given an additional course of a combination of anti. Dexamethasone, cyclophosphamide, etoposide and cisplatin dcep for relapsed or refractory multiple myeloma patients. Serum protein electrophoresis spep is a test that measures the antibodies in the blood and can find a monoclonal antibody. The links above go to a flowsheet to aid in the determination of disease. Dcep is the acronym for a chemotherapy regimen used in the treatment of multiple myeloma d. Aggressive relapsed and refractory extramedullary multiple myeloma is often treated with salvage infusional.
Conversely, a 4drug regimen combining bortezomib, lenalidomide. First described in 1848, mm is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein m protein. Electrophoresis the antibody produced by myeloma cells is abnormal because it is monoclonal all the. Powerpoint is the worlds most popular presentation software which can let you create professional myeloma powerpoint presentation easily and in no time. Although its cause is not certain, the increased occurrence of multiple. The aim of this study was to evaluate the efficacy of dcep in mobilizing pbsc and to define its toxicity. Dexamethasone, cyclophosphamide, etoposide, and cisplatin dcep is one of the salvage options, but there has been a lack of data on salvage dcep in patients with previous exposure to novel agents. Free download myeloma powerpoint presentation slides. Multiple myeloma is a cancer of plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body.
This is a pdf file of an unedited manuscript that has. Diagnosis typically requires demonstration of mprotein. From the myeloma unit, division of hematology, university of turin, aou characterized by clonal proliferation of malignant plasma cells in the s. Bortezomib was approved for the treatment of multiple myeloma in 2003. It is a highly manageable disease that has seen rapid medical advancements in the past few years. Multiple myeloma promotes osteoclastic activity, which causes not only the classic punched out lytic bone lesion image 2 but also vertebral compression fractures from general osteopenia. Each year in the united states, about 20,000 people learn they have this disease. Dcep for relapsed or refractory multiple myeloma after.
Common manifestations include lytic lesions in bones causing pain. It is one of the most frequently used medications in the treatment of multiple myeloma. In multiple myeloma, the level of one type may be high while the others are low. Thrombogenic activity of doxorubicin in myeloma patients receiving. From the myeloma unit, division of hematology, university of turin, aou characterized by clonal proliferation of. Cancer therapy selection, dosing, administration, and the management of related adverse events can be a complex process that should be handled by an experienced healthcare team. Your doctor will examine you and ask about your symptoms, medical history and overall health. Patients may present with bone pain or with symptoms that are often nonspecific, such as nausea.
Multiple myeloma is often diagnosed based on tests, the patients symptoms and the doctors physical exam of the patient. Nov 16, 20 multiple myeloma remains incurable despite the use of novel agents. Little is known, however, about its potential as mobilizing therapy. Multiple myeloma from greek myelo, bone marrow, also known as plasma cell myeloma or kahlers disease after otto kahler, is a cancer of plasma cells, a type of white blood cell normally. Kyprolis carfilzomib is indicated in combination with dexamethasone or with lenalidomide plus dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy.
Medical progress multiple myeloma antonio palumbo, m. Dexamethasone, cyclophosphamide, etoposide and cisplatin dcep. Dcep regimen buys time for multiple myeloma patients. How dcep chemotherapy is given and possible side effects.
Dcep is the acronym for a chemotherapy regimen used in the treatment of multiple myeloma d dexamethasone c cyclophosphamide cytoxan e etoposide vepesid p cisplatin platinol chemotherapy is often given as a combination of drugs. Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. Dexamethasone, cyclophosphamide, etoposide and cisplatin. Treatment and management of multiple myeloma full federal.
Request pdf dcep for relapsed or refractory multiple myeloma after therapy with novel agents multiple myeloma remains incurable despite the use of novel. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer. Kyprolis carfilzomib for relapsed or refractory multiple. Plasma cells make antibodies to help your body fight infection. Multiple cellular and molecular studies have shown that the. There was a 2003 paper that evaluated the use of bisphosphonates for skeletalrelated events in myeloma and in patients with metastatic breast cancer.
Only patients on dt pace but not dcept experienced an increased incidence of dvt. The combination of dexamethasone, cyclophosphamide, etoposide, and cisplatin dcep is an effective bridge to autologous stem cell transplant asct or novel agents in patients with. Dcep dexamethasone, cyclophosphamide, etoposide, and. The changing paradigm patient case and question a 65yearold violinist is diagnosed with myeloma and receives revlimid, velcade, and dexamethasone rvd. Hct is planned as part of initial therapy wout prior disease progression or relapse. The changing paradigm patient case and question a 65yearold violinist is diagnosed with myeloma and receives revlimid, velcade, and dexamethasone rvd followed by highdose melphalan and stem cell transplantation and revlimid maintenance. Dadacaridou m1, papanicolaou x, maltesas d, megalakaki c, patos p, panteli k. Myeloma cells usually proliferate in the bone marrow. Multiple myeloma ppt free download as powerpoint presentation. Multiple myeloma is a rare type of cancer that initially has few or no symptoms. Commonly used regimens include dcep, cvad, and vtdpace.
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